期刊
JOURNAL OF IMMUNOLOGY
卷 168, 期 9, 页码 4262-4267出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.168.9.4262
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- NCI NIH HHS [CA85721, CA09127] Funding Source: Medline
- PHS HHS [79915] Funding Source: Medline
Interaction between dendritic cells (DCs) and T cells is a prerequisite for the initiation of a T cell response. The molecular nature of this interaction remains to be fully characterized. We report in this work that freshly isolated mouse splenic DCs and bone marrow-derived DCs express CD137 on the cell surface and in soluble form. Triggering CD137 increased the secretion of IL-6 and IL-12 from DCs. More importantly, infusion of an agonistic mAb to CD137 into naive mice enhanced the ability of DCs to stimulate T cell proliferation in response to both alloantigens and a nominal Ag in vitro. This enhancement of DC function is not mediated through activation of T cells, because the effect was also observed in RAG-1 knockout mice that lack T cells. Our findings implicate CD137 as an important receptor involved in the modulation of DC function.
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