期刊
NEPHRON
卷 91, 期 1, 页码 34-42出版社
KARGER
DOI: 10.1159/000057602
关键词
asymptomatic urinary abnormalities; mass screening; IgA nephropathy
Aim: To elucidate prognosis and prevalence of chronic renal diseases among proteinuric and/or hematuric subjects found in mass screening, a long-term follow-up study (6.35 years, range 1.03-14.6 years) was conducted on Japanese working men. Methods: A total of 772 subjects selected from 50,501 Japanese men aged 15-62 years were found to have asymptomatic hematuria (n=404), concomitant hematuria and proteinuria (n=155), and proteinuria (n=213) during their annual urine examination and five consecutive urinalyses. Results: Hematuria patients showed significant improvements in urinary abnormalities as compared with both hematuria/proteinuria and proteinuria patients. Both hematuria/proteinuria patients with normotension and hematuria/proteinuria patients aged under 40 years showed significant improvements. During the follow-up period, 9.5% of the hematuria patients became hematuric/proteinuric. Hematuria/proteinuria patients had the highest risk of developing renal insufficiency. The presence of hypertension at detection of urinary abnormalities did not affect the renal function; however, if proteinuria appeared after the age of 40 years, these patients had a higher risk of developing renal insufficiency. The incidence of IgA nephropathy in the present subjects was as high as 143 cases per 1 million per year. Conclusion: Detailed follow-up and definitive diagnosis of asymptomatic urinary abnormalities may raise the prevalence of IgA nephropathy worldwide. Copyright (C) 2002 S. Karger AG, Basel.
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