期刊
CELL
卷 109, 期 3, 页码 397-407出版社
CELL PRESS
DOI: 10.1016/S0092-8674(02)00719-5
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资金
- NIAID NIH HHS [R01 AI46734, R01 AI50200] Funding Source: Medline
- NIGMS NIH HHS [R01 GM64091] Funding Source: Medline
- NINDS NIH HHS [R01 NS40927] Funding Source: Medline
Calcium-activated nonselective (CAN) cation channels are expressed in various excitable and nonexcitable cells supporting important cellular responses such as neuronal bursting activity, fluid secretion, and cardiac rhythmicity. We have cloned and characterized a second form of TRPM4, TRPM4b, a member of the TRP channel family, as a molecular candidate of a CAN channel. TRPM4b encodes a cation channel of 25 pS unitary conductance that is directly activated by [Ca2+]i with an apparent K-D of similar to400 nM. It conducts monovalent cations such as Na+ and K+ without significant permeation of Ca2+. TRPM4b is activated following receptor-mediated Ca2+ mobilization, representing a regulatory mechanism that controls the magnitude of Call influx by modulating the membrane potential and, with it, the driving force for Ca2+ entry through other Ca2+-permeable pathways.
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