期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 67, 期 9, 页码 2789-2797出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo0159800
关键词
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alpha,beta-Didehydroglutamates have been diastereoselectively transformed into 6-oxoperhydropyridazine-3-carboxylic acid derivatives (OPCAs), which constitute a new class of cyclic amino acid derivatives. Acylation at N-1 renders dipeptides which show considerable conformational rigidity. Semiempirical calculations suggest that OPCAs might force peptide turns with different amplitudes depending on the substitution pattern and relative stereochemistry of the substituents of the pyridazinone ring.
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