期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 12, 期 9, 页码 1295-1298出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(02)00140-3
关键词
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Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Sre SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised. (C) 2002 Elsevier Science Ltd. All rights reserved.
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