期刊
NEUROREPORT
卷 13, 期 6, 页码 809-811出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200205070-00015
关键词
biphasic; corticospinal tract; monophasic; motor cortex; plasticity; repetitive transcranial magnetic stimulation; stimulus configuration
In a blinded cross-over design, 10 healthy controls received 900 monophasic and biphasic repetitive transcranial magnetic stimuli over the primary motor cortex. Stimulation frequency was 1 Hz, and stimulation intensity 90% of the individual resting motor threshold. Suprathreshold stimuli applied at 0.1 Hz before and after repetitive stimulation controlled for changes in corticospinal excitability. We found a lasting corticospinal inhibition that was significantly more pronounced after monophasic than after biphasic repetitive transcranial magnetic stimulation (motor evoked potential amplitude reduced by 35 +/- 20% vs 12 +/- 37%, mean +/- s.d). We propose that the current flow in the coil plays a significant role in optimising after effects, and asymmetric current flow may be particularly efficient in building up tissue polarization. NeuroReport 13:809-811 (C) 2002 Lippincott Williams Wilkins.
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