期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 293, 期 3, 页码 1077-1083出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0006-291X(02)00325-X
关键词
bile; bilirubin; biliverdin reductase; Gunn rat; liver; organic anion
资金
- NICHD NIH HHS [HD17779] Funding Source: Medline
- NIDDK NIH HHS [DK26307] Funding Source: Medline
- NIGMS NIH HHS [GM36633] Funding Source: Medline
Multidrug resistance protein 2 (Mrp2) is considered the major mammalian membrane transporter of non-bile salt organic anions from liver to bile. Using Mrp2-deficient rats. we show that the protein is not essential for biliary excretion of biliverdin, its IIIalpha and XIIIalpha isomers. mesobiliverdin XIIIalpha or biliverdins bearing bulky lipophilic groups that are not reduced by biliverdin reductase in vivo. Yet, Mrp2 deficiency does retard the biliary excretion of these verdins to different degrees. The data indicate that there are Mrp2-independent mechanisms in the rat for biliary excretion of dicarboxylate organic anions related to biliverdin. (C) 2002 Elsevier Science (USA). All rights reserved.
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