期刊
JOURNAL OF CELL BIOLOGY
卷 157, 期 4, 页码 565-570出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200202010
关键词
p75; neurotrophin; myelin-associated glycoprotein; Rho; ganglioside
类别
Myelin-associated glycoprotein (MAG) is a potent inhibitor of neurite outgrowth from a variety of neurons. The receptor for MAG or signals that elicit morphological changes in neurons remained to be established. Here we show that the neurotrophin receptor p75 (p75(NTR)) is the signal transducing element for MAG. Adult dorsal root ganglion neurons or postnatal cerebellar neurons from mice carrying a mutation in the p75(NTR) gene are insensitive to MAG with regard to neurite outgrowth. MAG activates small GTPase RhoA, leading to retarded outgrowth when p75(NTR) is present. Colocalization of p75(NTR) and MAG binding is seen in neurons. Ganglioside GT1b, which is one of the binding partners of MAG, specifically associates with p75(NTR). Thus,p75(NTR) and GT1b may form a receptor complex for MAG to transmit the inhibitory signals in neurons.
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