期刊
JOURNAL OF INFECTIOUS DISEASES
卷 185, 期 10, 页码 1409-1416出版社
UNIV CHICAGO PRESS
DOI: 10.1086/340614
关键词
-
资金
- NIAID NIH HHS [AI-39004, AI-41110, AI-33835, AI-36214, AI-27563] Funding Source: Medline
Human immunodeficiency virus (HIV) type 1 DNA in peripheral blood mononuclear cells (PBMC) was quantified in 31 children who received efavirenz, nelfinavir, and 1 or 2 nucleoside reverse-transcriptase inhibitors for greater than or equal to 2 years and in whom undetectable plasma HIV-1 RNA levels (<50 copies/mL) were sustained, to determine the usefulness of HIV-1 DNA as a marker of virus suppression. The median baseline HIV-1 DNA level was 750 copies/10(6) PBMC. After initiation of highly active antiretroviral therapy (HAART), HIV-1 DNA levels decreased gradually, reaching a plateau from week 80 through week 104 (median HIV-1 DNA level, 263 copies/10(6) PBMC). Children who had plasma HIV-1 RNA levels, 50 copies/mL after receiving HAART for 8 weeks (n = 16) had persistently lower quantities of intracellular HIV-1 DNA than children whose HIV-1 RNA levels reached, 50 copies/mL after 8 weeks of HAART (n = 15). The median half-life for intracellular HIV-1 DNA was 60 weeks. Thus, despite prolonged maintenance of undetectable levels of plasma HIV-1 RNA, HIV-1 DNA remains detectable in PBMC of children and may be a useful marker of further virus suppression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据