期刊
JOURNAL OF NEUROSCIENCE
卷 22, 期 10, 页码 -出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.22-10-j0003.2002
关键词
GABA affinity; tonic inhibition; phasic inhibition; competitive GABA(A) antagonist; SR95531; IPSC amplitude quantification
资金
- NINDS NIH HHS [NS 30549] Funding Source: Medline
A tonic inhibitory conductance mediated by GABA(A) receptors that supplements the phasic inhibition produced by IPSCs has been identified in the hippocampus and cerebellum. It is presently unknown whether tonic and phasic inhibitions are mediated by GABA(A) receptors with different subunit assemblies. Here we demonstrate that a low concentration (200 nM) of the highly specific competitive GABA(A) antagonist SR95531 (gabazine) reduces phasic inhibition in hippocampal granule cells by 71% but has no effect on tonic inhibition, whereas a high concentration (10 muM) of the antagonist blocked both conductances. These findings are consistent with tonic and phasic conductances being mediated by different GABA(A) receptor subtypes with different affinities for GABA.
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