期刊
TALANTA
卷 57, 期 2, 页码 333-341出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0039-9140(02)00024-3
关键词
micellar electrokinetic chromatography (MEKC); clobazam; clorazepate; flurazepam; flunitrazepam
The separation of four benzodiazepines (Flurazepam, Flunitrazepam, Clobazam and Clorazepate) in pharmaceutical products by micellar electrokinetic chromatography (MEKC) is described. It was carried out at 25 degreesC and 25 kV by using a 57 cm (50 cm to the detector) x 75 mum i.d. fused silica capillary and a 15 mM borate buffer (pH 9.2), 35 mM sodium dodecylsulfate (SDS) and 35 mM sodium deoxycholate water solution. Under these conditions, the analysis was performed in 8 min with acceptable limits of quantification (between 3 and 5 mg 1(-1)). The method has been applied for quantifying these benzodiazepines in serum and different commercial formulations with recoveries near 100%. (C) 2002 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据