Convenient synthesis of Cbz-protected β-amino ketones by a copper-catalysed conjugate addition reaction

A convenient synthesis of Cbz-protected beta-amino ketones is reported. Benzyl carbamates and alpha,beta-unsaturated ketones furnish the conjugate addition products in the presence of a Cut(II) catalyst Under mild conditions. Other weakly basic nitrogen nucleophiles can also be Used in this reaction. (C) 2002 Elsevier Science Ltd. All rights reserved.