Microwave-assisted Niementowski reaction. Back to the roots

In a search to speed up an aspect of the discovery processes, the Niementowshi synthesis of the 3H-quinazolin-4-one core as reinvestigated using microwave irradiation. The experimental methodology and microwave conditions described here are ell established, allowing significant rate enhancements and good yields compared to conventional reaction conditions. (C) 2002 Elsevier Science Ltd. All rights reserved.