期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1582, 期 1-3, 页码 81-88出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1388-1981(02)00140-3
关键词
G protein-coupled receptor; sphingosylphosphorylcholine; lysophosphatidylcholine; ovarian cancer G protein-coupled receptor 1; G2A; G protein-coupled receptor 4
资金
- NCI NIH HHS [R21 CA84038-01] Funding Source: Medline
In recent years, certain lysophospholipids (lyso-PLs) have been recognized as important cell signaling molecules. Among them, two phosphorylcholine-containing lyso-PLs, sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), have been shown to be involved in many cellular processes and are produced under physiological and pathological conditions. Although signaling properties of SPC and LPC have been studied in a variety of cellular systems, specific cell membrane receptors for SPC and LPC have not been identified previously. Recently, ovarian cancer G protein-coupled receptor 1 (OGR1, also known as GPR68), G protein-coupled receptor 4 (GPR4), and G2A have been identified as receptors for SPC and LPC. The signaling and ligand-binding properties of these receptors are reviewed here. These discoveries provide an intriguing opportunity and a novel approach in studying the pathophysiological roles of SPC and LPC and their receptors. (C) 2002 Elsevier Science B.V. All rights reserved.
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