期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1582, 期 1-3, 页码 257-264出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1388-1981(02)00179-8
关键词
lysophosphatidic acid; Edg receptor; cell survival; ovarian cancer; cancer therapy
资金
- NCI NIH HHS [CA82716, CA64602] Funding Source: Medline
Lysophosphatidic acid (LTA) is a naturally occurring phospholipid that exhibits pleiotrophic biological activities, ranging from rapid morphological changes to long-term cellular effects such as induction of gene expression and stimulation of cell proliferation and survival on a wide spectrum of cell types. LPA binds and activates distinct members of the Edg/LP subfamily of G protein-coupled receptors that link to multiple G proteins including G(i), G(q) and G(12/13) to elicit cellular responses. LPA plays a critical role as a general growth, survival and pro-angiogenic factor, in the regulation of physiological and pathophysiological processes in vivo and in vitro. Our previous work indicates that abnormalities in LPA metabolism and function in ovarian cancer patients may contribute to the initiation and progression of the disease. Thus, LPA could be a potential target for cancer therapy. This review summarizes evidence that implicates LPA in the pathophysiology of human ovarian cancer and likely other types of human malignancies. (C) 2002 Elsevier Science B.V. All rights reserved.
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