期刊
AIDS
卷 16, 期 8, 页码 1103-1111出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002030-200205240-00003
关键词
AIDS; CD4 T cells; growth hormone; immune-based therapy; immune reconstitution; thymus
资金
- NCRR NIH HHS [RR00083-39, RR00083-39S1] Funding Source: Medline
- NIAID NIH HHS [AI40312, AI47062, AI01597] Funding Source: Medline
- NIDDK NIH HHS [DK45833, DK54615] Funding Source: Medline
Objective: To determine whether treatment with growth hormone (GH) enhances thymopoiesis in individuals infected with HIV-1. Methods: Five HIV-1-infected adults were treated with GH for 6-12 months in a prospective open-label study. Immunological analyses were performed before GH treatment and repeated at 3 month intervals after GH initiation. Thymic mass was analysed using computed tomography with quantitative density and volume analysis. Analysis of circulating lymphocytes, including naive and memory T cell subsets, was performed using multiparameter flow cytometry. Results: GH treatment was associated with a marked increase in thymic mass in all CH recipients. Circulating naive CD4 T cells also increased significantly in all patients during GH therapy, suggesting an enhancement of thymopoiesis. Conclusion: GH has significant effects on the human immune system, including the reversal of thymic atrophy in HIV-1-infected adults. De-novo T cell production may thus be inducible in immunodeficient adults. (C) 2002 Lippincott Williams Wilkins.
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