期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 67, 期 11, 页码 3908-3910出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo0108717
关键词
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An enantioseletive synthesis of the novel anti-asthma agent IRL576,092 (2) is described. The synthetic route developed involves stereoselective 1,2-reduction of the enone carbonyl functionality of 6 and subsequent hydroboration as the key steps. Starting from the commercially available 5-androsten-3beta-ol-17-one 3, this approach affords IPL576,092 (2) in nine steps with overall yields of 25%, employing a limited number of chromatographic steps.
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