PI 3-kinases and PTEN: How opposites chemoattract

Phosphatidylinositol lipids, such as PI(4,5)P-2 and PI(3,4,5)P-3, are key mediators in diverse intracellular signaling pathways. Two recent reports examine how the metabolism of these lipids by phosphatidylinositol 3-kinases and the PTEN 3-phosphoinositide phosphatase may coordinate G protein coupled signaling pathways during eukaryotic chemotaxis.