期刊
DRUG RESISTANCE UPDATES
卷 5, 期 3-4, 页码 131-146出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/S1368-7646(02)00003-1
关键词
xiap; PI3K/Akt; ovarian cancer; chemoresistance
资金
- NCI NIH HHS [CA89242] Funding Source: Medline
Although cisplatin derivatives are first-line chemotherapeutic agents for the treatment of epithelial ovarian cancer, chemoresistance remains a major hurdle to successful therapy and the molecular mechanisms involved are poorly understood. Apoptosis is the cellular underpinning of cisplatin-induced cell death, which is associated with expression of specific death genes and down-regulation of survival counterparts. The X-linked inhibitor of apoptosis proteins (Xiap), an intracellular anti-apoptotic protein, plays a key role in cell survival by modulating death signaling pathways and is a determinant of cisplatin resistance in ovarian cancer cells in vitro. This review focuses on the role of Xiap and its interactions with the phosphoinositide-3 kinase (PI3K)/Akt cell survival pathway in conferring resistance of ovarian cancer cells to chemotherapeutic agents and discusses potential therapeutic strategies in overcoming chemoresistant ovarian cancer. (C) 2002 Elsevier Science Ltd. All rights reserved.
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