期刊
JOURNAL OF INFECTIOUS DISEASES
卷 185, 期 11, 页码 1672-1676出版社
UNIV CHICAGO PRESS
DOI: 10.1086/340521
关键词
-
It has been demonstrated that human immunodeficiency virus type 1 (HIV-1) replication persists in most infected individuals receiving highly active antiretroviral therapy (HAART). However, studies addressing the relationship between low levels of ongoing viral replication and immunologic parameters, such as the CD4(+):CD8(+) T cell ratio, in such individuals have been lacking. Here, a statistically significant inverse correlation is shown between the frequency of CD4(+) T cells carrying HIV-1 proviral DNA and the CD4(+):CD8(+) T cell ratio in infected individuals receiving HAART and in whom plasma viremia had been suppressed below the limit of detection for prolonged periods of time. No correlation was found between the frequency of HIV-1-specific cytotoxic CD8(+) T lymphocytes (CTLs) and the CD4(+):CD8(+) T cell ratios in those individuals. These data suggest that persistent, low-level, ongoing viral replication, although not sufficient to maintain HIV-1 specific CTL responses, may explain, in part, why normalization of the CD4(+):CD8(+) T cell ratio is not achieved in some infected individuals successfully treated with HAART.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据