期刊
CURRENT OPINION IN LIPIDOLOGY
卷 13, 期 3, 页码 267-272出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00041433-200206000-00006
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Recent literature provides a basis for understanding the behavioral, functional, and structural consequences of nutritional deprivation or disease-related abnormalities of n-3 polyunsaturated fatty acids. The literature suggests that these effects are mediated through competition between n-3 and n-6 polyunsaturated fatty acids at certain enzymatic steps, particularly those involving polyunsaturated fatty acid elongation and desaturation. One critical enzymatic site is a Delta(6)-desaturase. On the other hand, an in-vivo method in rats, applied following chronic n-3 nutritional deprivation or chronic administration of lithium, indicates that the cycles of de-esterification/re-esterification of docosahexaenoic acid (22:6n-3) and arachidonic acid (20:4n-6) within brain phospholipids operate independently of each other, and thus that the enzymes regulating each of these cycles are not likely sites of n-3/n-6 competition. Curr Opin Lipidol 13:267-272. (C) 2002 Lippincott Williams Wilkins.
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