期刊
PLANT MOLECULAR BIOLOGY
卷 49, 期 3-4, 页码 401-409出版社
SPRINGER
DOI: 10.1023/A:1015203013208
关键词
auxin; cullin; Nedd8; RUB; SCF; ubiquitin
资金
- PHS HHS [43644] Funding Source: Medline
Auxin-regulated gene expression is mediated by two families of transcription factors. The ARF proteins bind to a conserved DNA sequence called the AuxRE and activate transcription. The Aux/IAA proteins repress ARF function, presumably by forming dimers with ARF proteins. Recent genetic studies in Arabidopsis indicate that auxin regulates this system by promoting the ubiquitin-mediated degradation of the Aux/IAA proteins, thus permitting ARF function. Mutations in components of SCFTIR1, a ubiquitin protein ligase (E3) result in stabilization of Aux/IAA proteins and decreased auxin response. Further, recent biochemical experiments indicate that the Aux/IAA proteins bind SCFTIR1 in an auxin-dependent manner.
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