期刊
APOPTOSIS
卷 7, 期 3, 页码 247-260出版社
SPRINGER
DOI: 10.1023/A:1015312119693
关键词
anoikis; apoptosis; cadherins; detachment-induced apoptosis; integrins
Apoptosis following loss of cell anchorage is of relevance for development, tissue homeostasis and disease. In the following the role of cell-matrix anchorage as well as cell-cell anchorage for cell survival and apoptosis is reviewed and the complex molecular mechanisms inducing and perpetuating detachment-induced apoptosis will be discussed with special emphasis on the role of caspases, p53, bcl-2 family members and the Fas signaling pathway.
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