期刊
MOLECULAR NEUROBIOLOGY
卷 25, 期 3, 页码 213-231出版社
SPRINGER
DOI: 10.1385/MN:25:3:213
关键词
tau; hyperphosphorylated tau; paired helical filaments; neurofibrillary tangles; Alzheimer's disease; tauopathies; transgenic animal models; tau polymerization
Alzheimer's disease (AD) is the most usual neurodegenerative disorder leading to dementia in the aged human population. It is characterized by the presence of two main brain pathological hallmarks: senile plaques and neurofibrillary tangles (NFTs). NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau.
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