期刊
INTENSIVE CARE MEDICINE
卷 28, 期 6, 页码 705-711出版社
SPRINGER-VERLAG
DOI: 10.1007/s00134-002-1282-x
关键词
adrenergic beta-agonists; albuterol; alveolar fluid clearance; pulmonary edema
资金
- NHLBI NIH HHS [HL 51856] Funding Source: Medline
- PHS HHS [K08 70521] Funding Source: Medline
Objective: Experimental studies demonstrate that beta-adrenergic agonists markedly stimulate alveolar fluid clearance if concentrations of 10(-6) M are achieved in alveolar fluid. However, no studies have determined whether aerosolized beta-adrenergic agonists are delivered to the distal air spaces of the lung in therapeutic concentrations in patients with pulmonary edema. Design and setting: This retrospective study measured albuterol levels in the pulmonary edema fluid and plasma from mechanically ventilated patients with pulmonary edema from a hydrostatic mechanism (n=10) or from acute lung injury (n=12). Measurements and results: After a total aerosolized albuterol dose of 4.2 +/- 3.2 mg in the prior 6 h the median pulmonary edema fluid albuterol level was 1,250 ng/ml (10(-6) M) in patients with hydrostatic pulmonary edema; after 3.5 +/- 2.6 mg the figure was 1,240 ng/ml (10(-6) M) in patients with pulmonary edema from acute lung injury. Plasma albuterol levels were much lower, with a median of 5.2 ng/ml (0.0 1 x 10(-6) M) in patients with hydrostatic pulmonary edema and 3.1 ng/ml (0.01 x 10(-6) M) in patients with pulmonary edema from acute lung injury. Conclusions: These results provide the first evidence that levels of beta-adrenergic agonists that are physiologically efficacious in experimental models can be achieved with conventional delivery systems in ventilated, critically ill patients with acute respiratory failure from pulmonary edema.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据