期刊
TRENDS IN NEUROSCIENCES
卷 25, 期 6, 页码 284-286出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0166-2236(02)02169-0
关键词
-
Neurotrophins promote neuronal survival and differentiation by binding to two classes of cell surface receptors: members of the Trk-family receptor tyrosine kinases and p75(NTR), a member of the tumor necrosis factor receptor superfamily. The discoveries that the unprocessed proneurotrophin peptide Is both a preferential high-affinity ligand for p75NTR (with minimal affinity for trkA) and a potent inducer of p75(NTR)-mediated neuronal cell death are likely to change our understanding of neurotrophin physiology and our ability to manipulate their signaling pathways.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据