Electrically stimulated olfactory evoked potential in olfactory disturbance

Olfactory evoked potential is considered a useful method of electrophysiological olfactometry for the diagnosis of olfactory disturbance. However, electrophysiological olfactometry is not as widely used as electrophysiological audiometry, such as the auditory brain stem response. because odor stimulation is difficult to perform. In contrast. electrical pulse stimulation is easy to perform, and its evoked potential is also easily recorded by the averaging method. We recorded olfactory evoked potentials from the scalp produced by electrical stimulation on the olfactory mucosa and investigated the relationship between this electrical olfactory evoked potential (EOEP) and the results of Toyoda and Takagi's perfumist's strip method (T&T) olfactometry, which is a standard Japanese means of psychophysical olfactometry. In EOEP-detectable cases, the detection and cognitive thresholds of T&T olfactometry were 1.32 +/- 1.99 (mean +/- SD: n = 10) and 3.02 +/- 1.64 (n = 10), respectively. But in the undetectable cases, the thresholds were 4.67 +/- 2.03 (n = 8; 5.8 means off the scale) and 5.80 +/- 0.00 (n = 8), respectively. The differences between the T&T thresholds of EOEP-detectable and -undetectable cases were significant. We concluded that EOEP is suitable for electrophysiological olfactometry.