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High-speed combinatorial synthesis utilizing microwave irradiation

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CURRENT OPINION IN CHEMICAL BIOLOGY
卷 6, 期 3, 页码 314-320

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ELSEVIER SCI LTD
DOI: 10.1016/S1367-5931(02)00306-X

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Recent advances in microwave-assisted combinatorial chemistry include high-speed solid-phase and polymer-supported organic synthesis, rapid parallel synthesis of compound libraries, and library generation by automated sequential microwave irradiation. In addition, new instrumentation for high-throughput microwave-assisted synthesis continues to be developed at a steady pace. The impressive speed combined with the unmatched control over reaction parameters justifies the growing interest in this application of microwave heating.

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