期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 127, 期 1-2, 页码 115-126出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00068-1
关键词
HIV encephalitis; chemokines; Tat; SDF-1 alpha; neurite outgrowth
资金
- NIDA NIH HHS [DA 12065] Funding Source: Medline
- NIMH NIH HHS [MH 12549-01, MH 59745, MH 45294] Funding Source: Medline
Analysis of the patterns of stromal cell-derived factor la (SDF-1alpha) expression in the brains from HIV-positive patients suggests that in neuronal cells, SDF-1alpha might play a role in neuroprotection and neurite extension in response to HIV infection. In all cases analyzed, SDF- 1alpha immunoreactivity was primarily present in astroglial cells. Patients with HIV encephalitis (HIVE) showed intense somato-dendritic neuronal SDF-1alpha immunoreactivity, while HIVE negative patients with neurodegeneration had a significant decrease in neuronal SDF-1alpha immunoreactivity. Neuronal cells treated with SDF-1alpha displayed increased neurite outgrowth. similarly, neurons treated with HIV-Tat, which induced SDF-1alpha expression, also showed neurite outgrowth. Tat-mediated neurite outgrowth was blocked by anti-SDF-1alpha antibody. These results suggest that SDF-1alpha may play a role in the neuronal response to HIV in the brains of AIDS patients. (C) 2002 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据