The role of cytokines in the pathogenesis of Cryptosporidium infection

First described in 1912, the importance of the coccidian parasite Cryptasporidium parvum as an enteropathogen in humans was not recognized until the early 1980s, when it was found to be a common opportunistic infection in AIDS. Infection with this organism triggers a complex array of innate and cell-mediated immune responses within the intestinal mucosa. How cytokines and chemokines interact to regulate these responses in order to achieve clearance of the parasite yet preserve the integrity of the intestinal mucosa is still being unravelled. T helper type 1 cytokines, and particularly interferon-gamma, have long been considered to be the main orchestrators of the immune response to this infection, but recent studies suggest that T helper type 2 cytokines may also be involved. In addition, transforming growth factor-beta1, although having little effect on parasite development, is an important modulator of the immune response and plays a role in protecting the epithelial integrity from the effects of the inflammatory process.