期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 19, 期 6, 页码 461-465出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0924-8579(02)00102-4
关键词
Proteus mirabilis; urinary tract infection; urolithiasis; vaccine; urease; MR/P fimbria
Proteus mirabilis is a documented cause of urinary tract infection (UTI) in the complicated urinary tract. Urease-mediated urea hydrolysis is responsible for both virulence of the organism and the ability to cause urolithiasis. A urease-negative mutant of P. mirabilis is unable to initiate stone formation and colonizes the kidney at a significantly lower rate. The considerable pathology caused by P. mirabilis warrants the development of a vaccine. We have initiated the advancement of vaccine studies and have determined that the MR/P fimbria, a surface adhesin of P. mirabilis, is a promising vaccine candidate. Successful vaccination would be expected both to prevent colonization by P. mirabilis and urolithiasis. (C) 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.
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