期刊
JOURNAL OF BACTERIOLOGY
卷 184, 期 12, 页码 3392-3395出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.184.12.3392-3395.2002
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- NIAID NIH HHS [R01 AI033706, AI-33706] Funding Source: Medline
It was determined that the dTDP-rhamnose synthesis gene, rmlD, could be inactivated in Mycobacterium smegmatis only in the presence of a rescue plasmid carrying functional rmlD. Hence, dTDP-rhamnose biosynthesis is essential for the growth of mycobacteria and the targeting of dTDP-rhamnose synthesis for new tuberculosis drugs is supported.
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