期刊
MOLECULAR NEUROBIOLOGY
卷 25, 期 3, 页码 245-263出版社
SPRINGER
DOI: 10.1385/MN:25:3:245
关键词
dopamine neurons; glial cells; tyrosine hydroxylase; L-DOPA; MPP; nitric oxide; antioxidants; growth factors; apoptosis; Bcl-2 family proteins; MAP kinases; Parkinson's disease
Glial cells play a key role in the function of dopamine (DA) neurons and regulate their differentiation, morphology, physiological and pharmacological properties, survival, and resistance to different models of DA lesion. Several studies suggest that glial cells may be important in the pathogenesis of Parkinson's disease (PD), a common neurodegenerative disorder characterized by degeneration of the nigrostriatal DA system. In this disease the role of glia could be due to the excessive production of toxic products such as nitric oxide (NO) or cytokines characteristic of inflammatory process, or related to a defective release of neuroprotective agents, such as small antioxidants with free radical scavenging properties or peptidic neurotrophic factors.
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