期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 12, 期 3, 页码 339-345出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-4388(02)00331-8
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Recent studies using molecular genetics in mice and dogs, as well as histopathological analyses of human disease, have come to the same conclusion: the human sleep disorder narcolepsy is caused by failure of signaling mediated by orexin (hypocretin) neuropeptides. These and other findings strongly suggest that the orexin system plays a critical role in sleep/wake regulation. In addition, the orexin system may link energy homeostasis to the regulation of sleep/wake cycles.
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