期刊
PLASMAS AND POLYMERS
卷 7, 期 2, 页码 89-101出版社
KLUWER ACADEMIC/PLENUM PUBL
DOI: 10.1023/A:1016250718123
关键词
micropatterning; cell adhesion; wettability; alginate; polysaccharides; surface modification; plasma
Air plasma treatment, coupled to a masking technique, was used to promote micropatterned cell adhesion onto a cell-adhesion-resistant alginate coated surface. L-929 mouse fibroblasts were successfully confined into 50 mum diameter cell-adhesive areas patterned inside a cell-resistant layer. The plasma treatment performed, albeit very mild, destroys the molecular architecture of the hydrophilic polysaccharide coating, leading to an enhancement of protein adsorption and hence of cell-adhesion. Both the cell-adhesion-resistant and the cell-adhesive regions are hydrophilic, yet they show a completely different behavior towards cells. Thus, they are a very interesting subject in the study of interfacial interactions in aqueous media, and, in particular, on the mechanisms of bio-adhesion at hydrophilic surfaces.
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