期刊
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
卷 61, 期 6, 页码 539-546出版社
AMER ASSN NEUROPATHOLOGISTS INC
DOI: 10.1093/jnen/61.6.539
关键词
integrins; microglia; MS pathogenesis; oligodendrocyte pathology; vascular cell adhesion molecule-1; very late activation antigen-4
资金
- NINDS NIH HHS [NS35058, NS07291, NS38667] Funding Source: Medline
The distribution and lineage of vascular cell adhesion molecule-1 (VCAM-1)-positive cells was investigated in 43 lesions from the brain tissue of patients with multiple sclerosis (MS). Numerous VCAM-1-positive macrophages/microglia were detected at the edges of MS lesions. Quantitative analysis of 6 active, 7 chronic active, and 4 chronic inactive MS lesions identified most VCAM-1-positive cells at the actively demyelinating borders of active (102/mm(3)) and chronic active (29/mm(3)) lesions, but rarely in chronic inactive lesions (4/mm(3)). Further, approximately 17% of the VCAM-1-positive cells closely apposed or surrounded oligodendrocyte perikarya at the edges of active and chronic active lesions that were sites of ongoing demyelination. Endothelial cells were VCAM-1-negative in both lesion and non-lesion MS brain tissue. This report is the first to document direct microglial interaction with oligodendrocytes in MS.
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