期刊
BIOLOGICAL TRACE ELEMENT RESEARCH
卷 87, 期 1-3, 页码 171-182出版社
HUMANA PRESS INC
DOI: 10.1385/BTER:87:1-3:171
关键词
forced swimming stress; HSP; corticosterone; subsensitivity; taurine; taurine concentration; contractile force; sinus rate; rat heart
Modulation of the sinus rate and contractile force by taurine at different extracellular Ca2+ concentrations ([Ca2+](o)) was examined using rat right atria loaded with forced swimming stress. Serum concentration of corticosterone profoundly increased in stress-loaded rats as compared with native rats. The taurine level in serum also increased in stress-loaded rats, but was not changed in the different heart tissues and aorta. Heat-shock protein (HSP72) was detectable in cardiac muscles and in the lumen of cardiac blood vessels of stress-loaded rats using a monoclonal antibody. Increasing [Ca2+](o) (from 0.9 to 3.6 mM) enhanced the sinus rate and contractile force in a [Ca2+](o)-dependent fashion in native rats, but not in stress-loaded rats. Taurine (1-20 mM) caused a negative chronotropic and inotropic effect in a concentration-dependent manner. At 1.8 mM [Ca2+](o), the negative chronotropic effect of taurine (10-20 mM) was attenuated in stress-loaded rats as compared with native rats. These results indicate that swimming stress causes a release of taurine into the serum and reduces the sensitivity to [Ca2+](o). Taurine administration might, in part, exhibit the protective actions on acute stress-induced responses.
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