期刊
INFECTION AND IMMUNITY
卷 70, 期 6, 页码 3259-3263出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.70.6.3259-3263.2002
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资金
- NIAID NIH HHS [AI46516, R01 AI046516, AI33492] Funding Source: Medline
- NIGMS NIH HHS [R01 GM031318, GM31318] Funding Source: Medline
The Jacob lectin, the most abundant glycoprotein in the cyst wall of Entamoeba invadens, contains five unique 6-Cys chitin-binding domains (CBDs). We identified Entamoeba histolytica and Entamoeba dispar genes encoding Jacob homologues, each of which contains two predicted 6-Cys CBDs. A unique 8-Cys CBD was found at the N termini of the E. histolytica chitinase and three other predicted lectins, called Jessie I to Jessie 3. The CBDs of four E. histolytica lectins (Jacob, chitinase, and Jessies 2 and 3) were expressed in secretory vesicles of transfected amebae and shown to bind to particulate chitin.
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