期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 92, 期 6, 页码 2617-2624出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.01102.2001
关键词
aging; ragged red fiber; rat; muscle atrophy
资金
- NIA NIH HHS [R01 AG-17543, P01 AG-11915, R01 AG-11604] Funding Source: Medline
The hypothesis that the accumulation of electron transport system (ETS) abnormalities and sarcopenia are linked was investigated. Vastus lateralis, soleus, and adductor longus muscles were studied in 5-, 18-, and 36-mo-old male Fischer 344 x Brown Norway F-1 hybrid rats. A significant decrease in soleus and vastus lateralis muscle mass was observed with age. Adductor longus was resistant to muscle mass loss. Multiple serial sections were analyzed for the activities of cytochrome-c oxidase (COX) and succinate dehydrogenase (SDH). The number of fibers exhibiting a COX-/SDH++ phenotype increased with age in both vastus lateralis and soleus muscles. No ETS-abnormal fibers were identified in adductor longus at any age. Cross-sectional area of ETS-abnormal fibers decreased in the abnormal region (region displaying COX-/SDH++ phenotype), whereas control fibers did not. The vastus lateralis muscle, which undergoes a high degree of sarcopenia, exhibited more ETS abnormalities and associated fiber loss than the soleus and adductor longus muscles, which are more resistant to sarcopenia, suggesting a direct association between ETS abnormalities and fiber loss.
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