期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 12, 期 11, 页码 1525-1528出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(02)00169-5
关键词
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Using a virtual screening strategy based on a methodology derived from the CATS molecular descriptor, a novel compound class with inhibitory activity against the GSK-3 enzyme was identified through scaffold hopping. These compounds were readily synthesized, either by solid-phase or solution-phase chemistry. Compounds with inhibitory activity below 1 muM were identified. (C) 2002 Elsevier Science Ltd. All rights reserved.
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