期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 195, 期 11, 页码 1507-1512出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20020207
关键词
immunity; cytokines; imidazoquinolines; pathogen-associated molecular patterns; Th cell responses
Dendritic cells (DCs) play a crucial role in the immune responses against infections by sensing microbial invasion through toll-like receptors (TLRs). In humans, two distinct DC subsets, CD11c(-) plasmacytoid DCs (PDCs) and CD11c(+) myeloid DCs (MDCs), have been identified and can respond to different TLR ligands, depending on the differential expression of cognate TLRs. In this study, we have examined the effect of TLR-7 ligands on human DC subsets. Both subsets expressed TLR-7 and could respond to TLR-7 ligands, which enhanced the survival of the subsets and upregulated the surface expression of costimulatory molecules such as CD40, CD80, and CD86. However, the cytokine induction pattern was distinct in that PDCs and MDCs produced interferon (IFN)-alpha and interleukin (IL)-12, respectively. In response to TLR-7 ligands, the Th1 cell supporting ability of both DC subsets was enhanced, depending, on the cytokines the respective subsets produced. This study demonstrates that TLP-7 exerts its biological effect in a DC subset-specific manner.
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