期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 12, 页码 2362-2365出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm025522z
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Dipeptidyl peptidase IV (DPP-IV) inhibition has the potential to become a valuable therapy for type 2 diabetes. We report the first use of solid-phase synthesis in the discovery of a new DPP-I-V inhibitor class and a solution-phase synthesis that is practical up to the multikilogram. scale. One compound, NVP-DPP728 (2), is profiled as a potent, selective, and short-acting DPP-I-V inhibitor that has excellent oral bioavailability and potent antihyperglycemic activity.
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