期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 12, 页码 2534-2542出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm010119y
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资金
- NCI NIH HHS [CA 44344-05-12, N01-CO-56000, R01 CA 90441-01] Funding Source: Medline
As an extension of structure/activity investigations of resveratrol (1), phenstatin (2c), and the cancer antiangiogenesis drug sodium combretastatin A-4 phosphate (2b), syntheses of certain related stilbenes (14) and benzophenones (16) were undertaken. The trimethyl ether derivative of (Z)-resveratrol (4a) exhibited the strongest activity (GI(50) = 0.01-0.001 mug/mL) against a minipanel of human cancer cell lines. A monodemethylated derivative (14c) was converted to prodrug 14n (sodium resverastatin phosphate) for further biological evaluation. The antitubulin and antimicrobial activities of selected compounds were also evaluated.
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