期刊
SCIENCE
卷 296, 期 5574, 页码 1869-1873出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1070051
关键词
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资金
- NIGMS NIH HHS [GM-48071, GM-41514] Funding Source: Medline
Lymphocyte motility is vital for trafficking within lymphoid organs and for initiating contact with antigen-presenting cells. Visualization of these processes has previously been, limited to in vitro systems. We describe the use of two-photon laser microscopy to image the dynamic behavior of individual living lymphocytes deep within intact lymph nodes. in their native environment, T cells achieved peak velocities of more than 25 micrometers per minute, displaying a motility coefficient that is five to six times that of B cells. Antigenic challenge changed T cell trajectories from random walks to swarms and stable clusters. Real-time two-photon imaging reveals lymphocyte behaviors that are fundamental to the initiation of the immune response.
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