期刊
SCIENCE
卷 296, 期 5574, 页码 1860-1864出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1068428
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资金
- NEI NIH HHS [R01 EY11030] Funding Source: Medline
- NIGMS NIH HHS [2T32GM07365] Funding Source: Medline
The central nervous system (CNS) loses the ability to regenerate early during development, but it is not known why. The retina has long served as a simple model system for study of CNS regeneration. Here we show that amacrine cells signal neonatal rat retina[ ganglion cells (RGCs) to undergo a profound and apparently irreversible loss of intrinsic axon growth ability. Concurrently, retinal. maturation triggers RGCs to greatly increase their dendritic growth ability. These results suggest that adult CNS neurons fail to regenerate not only because of CNS glial inhibition but also because of a loss of intrinsic axon growth ability.
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