期刊
NEUROSCIENCE LETTERS
卷 325, 期 2, 页码 124-128出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(02)00252-5
关键词
amyotrophic lateral sclerosis; oxidative stress; 1-methyl-4-phenyl-1;2;3;6-tetrahydropyridine; Parkinson's disease; reactive oxygen species; superoxide dismutase
Recent data indicate that overexpression of the enzyme Cu,Zn superoxide dismutase (SOD1) in mice confers neuroprotection against various dopamine neurotoxins like 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), methamphetamine, 6-hydroxydopamine and methylenedioxymethamphetamine, In the present study we investigated whether a mutant form of SOD1 (G93A), occurring in humans affected by amyotrophic lateral sclerosis, leads to a differential vulnerability of nigrostriatal dopaminergic neurons to the chronic dopamine depletion induced by the selective neurotoxin MPTP. Our results indicate that overexpression of both wild-type and human mutant SOD1 induces comparable neuroprotective effects against striatal dopaminergic depletion. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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