期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 67, 期 12, 页码 4115-4121出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo016275u
关键词
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Treatment of acylnitroso hetero Diels-Alder cycloadducts 2 with organomagnesium reagents in the presence of a catalytic amount of copper induces ring opening to afford predominantly monocyclic anti-1,2-hydroxamic acids 12. Alkylmagnesium reagents were found to give superior regio- and stereoselectivities compared with vinyl and arylmagnesium reagents. This cycloadduct ring opening methodology was applied to the synthesis of a unique cyclopentenyl hydroxamic acid-based inhibitor of 5-lipoxygenase.
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