期刊
NEUROSCIENCE LETTERS
卷 325, 期 3, 页码 191-194出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(02)00291-4
关键词
methamphetamine; p53; DNA-binding activity; superoxide dismutase; reactive oxygen species
The striatal DNA-binding activities of p53 as a transcription factor were gradually increased at several days after a single methamphetamine (METH) injection, while they were more rapidly increased within several hours after repeated METH injections (x 4 with a 2 h interval). The elevation of striatal p53 DNA-binding after repeated METH injections was markedly attenuated in Cu,Zn-superoxide dismutase transgenic mice, but not affected by treatments with N-methyl-Daspartate or D1 receptor antagonists. The present results suggest that METH-induced production of reactive oxygen species activates striatal p53 DNA-binding activity; this, in turn, may activate other downstream pathways that are responsible for chronic neurotoxicity of METH. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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