期刊
JOURNAL OF IMMUNOLOGY
卷 168, 期 12, 页码 6500-6505出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.168.12.6500
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- NIAID NIH HHS [AI 39816] Funding Source: Medline
The effect of steroid treatment on the thymic output of T cells was examined in an avian model. Recent thymic emigrants in chickens transiently express the chicken T cell Ag 1 thymocyte marker, and thymic function can be monitored indirectly by measuring the levels of TCR gene rearrangement excision circles in peripheral T cells. Both parameters were used to show that intensive steroid treatment induces thymic involution and a profound reduction in the supply of naive T cells to the periphery. Conversely, resident T cells in the peripheral lymphocyte pool were relatively spared. Thymopoiesis immediately recovered following cessation of steroid treatment, concurrent with restoration of the thymic output of newly formed T cells. Repopulation of the peripheral T cell pool recapitulated the ontogenetic pattern of gammadelta T cell replenishment before alphabeta T cell reseeding, thereby indicating the complete recovery of thymic function after a course of steroid treatment.
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