期刊
FEMS MICROBIOLOGY LETTERS
卷 212, 期 1, 页码 101-106出版社
OXFORD UNIV PRESS
DOI: 10.1016/S0378-1097(02)00735-8
关键词
Pseudomonas aeruginosa; rhlI regulation; quorum sensing
类别
资金
- NIAID NIH HHS [R01 AI046682, AI 133713, R01 AI 46682] Funding Source: Medline
In Pseudomonas aeruginosa the LasR-LasI and RhlR-RhlI quorum-sensing (QS) systems control expression of numerous virulence genes in a population density-dependent fashion. In this study, we investigated regulation of the autoinducer synthase gene rhlI, which is responsible for C-4-HSL signal production. Primer extension analysis was used to map the rhlI transcriptional start site and an upstream regulatory region was identified. Expression studies revealed that (i) this regulatory region is important for rhlI expression and (ii) although the rhl QS system will induce rhlI, las is the dominant regulator. Furthermore, we found that control of rhlI in Escherichia coli is markedly different than in P. aeruginosa. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Microbiological Societies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据